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We have launched our renewed website.
http://lpsct.com/?page_id=31&lang=japanese

December 5, 2017
The 32^nd JBDA Bio-Venture Forum will be held at the Daiwa Ubiquitous Research Building, The University of Tokyo. https://jbda.org/921117467981/ (Japanese)

November 8, 2017
Hiroshi Tamura received a reviewer reward certificate from Spandidos Publications.
Reviewer_Certificate

October 29-November 2, 2017
The 5^th Annual Meeting of the International Cytokine & Interferon Society was successfully held by Prof. Kouji Matsushima (Tokyo University) .
http://icis2017japan.com/index.html

June 22, 2017
The 31^st JBDA Bio-Venture Forum will be held at the Daiwa Ubiquitous Research Building, The University of Tokyo. https://jbda.org/921117467981/ (Japanese)

April 12, 2017
Drs. Ryuji Kawaguchi (President & CEO, PropGene), and Dr. Hiroshi Tamura (Head of LPS Consulting Office) wrote a review article to the following journal.
Kawaguchi R, Tamura H, Rentschler E: Direct-to-consumer genotyping in pre-disease field in Japan and the United State. J Hum Biol & Health Edu 1: 002, 2017.⇒a monograph

March 19-20, 2017
The following paper was presented at the 90th Annual Meeting of Japanese Society for Bacteriology held at Sendai International Center, Sendai, Japan.
Human antimicrobial peptide LL-37 induces autophagy in endothelial cells.
Kaori Suzuki¹, Hiroshi Tamura^1,2, Isao Nagaoka¹ (¹Dept. Host Defense
and Biochem. Res., Sch. Med., Juntendo Univ., ²LPS Consulting Office)
https://www.jstage.jst.go.jp/article/jsb/72/1/72_71/_pdf (P-347)

February 10, 2017
Hiroshi Tamura updated his publication list (Literature).
http://www.lpsct.com/about.html

December 20, 2016
The 30^th Bio-Venture Forum will be held at the Sanjo Conference Hall, The University of Tokyo. http://www.jbda.org/seminar/index.html (Japanese)

December 2-3, 2016
The 22^nd Annual Japan Endotoxin & Innate Immunity Society (JEIIS) meeting was organized by Prof. Yasuo Suda (Kagoshima University) . Dr. Kaori Suzuki of Juntendo University was awarded JEIIS Award for Research Excellence in Roles of Host Defense Peptides.

October 1-2, 2016
The 60^th Annual Meeting of the Japanese Society for Medical Mycology meeting was held in Asakusa, Tokyo (Conference Chair: Professor Naohito Ohno at Tokyo University of Pharmacy and Life Science) . The head of LPS Consulting Office, Dr. Hiroshi Tamura, and Prof. Ken Kikuchi of Tokyo Women's Medical University co-chaired the Symposium on Recent Progress and Future Perspective in Diagnosis of Invasive Fungal Diseases.
http://c2.shunkosha.com/jsmm2016/program.html(Japanese)

September 22-24, 2016
A recent paper on the roles of neutrophil extracellular traps (NETs) will be presented by Prof. Isao Nagaoka of Juntendo University School of Medicine at the 14^th Biennial Meeting of the International Endotoxin and Innate Immunity Society (IEIIS) to be held in Hamburg, Germany. http://www.ieiis2016.de/

July 8, 2016
The head of LPS Consulting Office, Dr. Hiroshi Tamura wrote the editor’s column　entitled “The Road to Next Generation LAL Technology” on EC Bacteriology and Virology Research (ECBVR). https://www.ecronicon.com/eco16/pdf/ECBVR-01-ECO-03.pdf

July 6, 2016
The head of LPS Consulting Office, Dr. Hiroshi Tamura was invited to join the panel of peer reviewers for Spandidos Publications. https://www.spandidos-publications.com/

July 1, 2016
A review article entitled “Bacterial Endotoxin Assays Relevant to Host Defense Peptides” was published in Juntendo Medical Journal, 2016.
Tamura H, Reich J, Nagaoka I: Juntendo Med J  62: 132-140, 2016. https://www.jstage.jst.go.jp/article/jmj/62/2/62_132/_pdf

June 23, 2016
The 29^th Bio-Venture Forum was organized by the Japan Bio-Venture Development Association (JBDA) at the Sanjo Conference Hall, The University of Tokyo.
http://www.jbda.org/seminar/index.html (Japanese)
The head of LPS Consulting Office, Dr. Hiroshi Tamura became the Exective Director of JBDA. He was also named the head of JBDA secretariat.

June 1, 2016
President & CEO of PropGene, Inc., Dr. Ryuji Kawaguchi started to provide next-generation sequencing and bioinformatics services. http://en.novogene.com/

March 23-25, 2016
The following paper was presented at the 89^th Annual Meeting of Japanese Society for Bacteriology held at the International House, Osaka, Japan.
NETs (neutrophil extracellular traps) induce the IL-1beta production by macrophages
Zhongshuang Hu¹, Kaori Suzuki¹, Hiroshi Tamura², Isao Nagaoka¹ (Dept. Host Defense and Biochem., Sch. Med., Juntendo Univ.¹, LPS Consulting Office²)
https://www.jstage.jst.go.jp/article/jsb/71/1/71_58/_pdf

January 14, 2016
The head of LPS Consulting Office, Dr. Hiroshi Tamura,was appointed a member of the Editorial Panel for EC Bacteriology and Virology Research (ECBVR).
https://www.ecronicon.com/ECBVR-EB.php

December 21, 2015
Hiroshi Tamura updated his publication list (patents, literature).
http://www.lpsct.com/about.html

December 10, 2015
The 28^th Bio-Venture Forum was organized by the Japan Bio-Venture Development Association (JBDA) at the Sanjo Conference Hall, The University of Tokyo.
http://www.jbda.org/seminar/index.html (Japanese)

December 4-5, 2015
The 21^st Annual Japan Endotoxin & Innate Immunity Society (JEIIS) meeting was organized by Dr. Naoki Hiki (Director, Gastric Surgery Department at the Cancer Institute Hospital of JFCR). Dr. Zhongshuang Hu of Juntendo University made an oral presentation of the latest study on NETs (neutrophil extracellular traps).
(Conference Program and Abstract Book, p.21)
http://www.shiga-med.ac.jp/~jesmail/_userdata/21thprogram.pdf (Japanese)

October 6-8, 2015
The head of LPS Consulting Office, Dr. Hiroshi Tamura, attended Biotechnica 2015 in Hannover (Europe's No.1 event for biotechnology, life sciences and laboratory technology).
http://thailand.ahk.de/uploads/media/BIOTECHNICA-2015_Information.pdf

September 18, 2015
Dr. Hiroshi Hosoda et al. published an interesting paper entitled “Evaluation of the lipopolysaccharide-induced transcription of the human TREM-1 gene in vitamin D3-matured THP-1 macrophage-like cells”, in International Journal of Molecular Medicine (36(5):1300-10, 2015).

September 1, 2015
The head of LPS Consulting Office, Dr. Hiroshi Tamura, became a council member of Gerson Lehrman Group (GLG).
http://glg.it/council-members/

May-July, 2015
The head of LPS Consulting Office, Dr. Hiroshi Tamura served as a guest lecturer in the undergraduate seminar in the field of immunology and biodefense at Tokyo University of Pharmacy and Life Science.

June 27, 2015
The 24^th annual meeting on endotoxin/lipopolysaccharide(LPS) research was organized by Dr. Shigeru Katsuta (Associate Professor, The University of Tokyo). It was held at the Nakajima Hall, Faculty of Agriculture, The University of Tokyo, Japan on June 27, 2015. The head of LPS Consulting Office, Dr. Hiroshi Tamura, served as a chairperson at the meeting.
http://www.juntendo.ac.jp/graduate/laboratory/labo/seikagaku_seitaibogyo/lps/(Japanese)

June 18, 2015
The 27^th Bio-Venture Forum was organized by the Japan Bio-Venture Development Association (JBDA) at the Sanjo Conference Hall, The University of Tokyo on June 18, 2015. The President of JBDA, Prof. Kouji Matsushima of Graduate School of Medicine, The University of Tokyo, chaired the meeting. The head of LPS Consulting Office, Dr. Hiroshi Tamura presented his previous work in the field of Limulus Amebocyte Lysate (LAL)-based endotoxin testing and beta-D-glucan assay technologies along with a wide range of topics.
Click here for more details
http://www.jbda.org/seminar/index.html(Japanese)

May 12, 2015
An article on LPS Consulting Office was published in Sunday Mainichi, Mainichi Shinbun Publishing Inc., Tokyo (in Japanese).
83T839383f815B968893FA202015.5.248140pdf

March 26-28, 2015
The following papers were presented at the 88th Annual Meeting of Japanese Society for Bacteriology held at the Nagaragawa Convention Center, Gifu, Japan.
1. Cell surface HS proteoglycans mediate the uptake of antimicrobial peptide LL-37-LPS complex by LSECs
Kaori Suzuki, Hiroshi Tamura, Isao Nagaoka (Dept. Host Defense and Biochemical Research, Juntendo Univ. Sch. Med.)
2. NETs (neutrophil extracellular traps) induce the IL-1beta production by macrophages
Zhongshuang Hu¹, Kaori Suzuki¹, Hiroshi Tamura², Isao Nagaoka¹ (Dept. Host Defense and Biochem., Sch. Med., Juntendo Univ.¹, LPS Consulting Office²)
http://www.aeplan.co.jp/jsb88/pdf/programP_en.pdf

February 17, 2015
The Low Endotoxin Recovery (LER) phenomenon was first reported by Genentech Inc. in April 2013. Since then the Food and Drug Administration (FDA) raised concerns about the potential false negative LAL test outcomes due to the masking of endotoxins in various drug product formulations with time. Dr. Patricia Hughes of FDA/Center for Drug Evaluation and Research (CDER) gave a presentation on FDA regulations and endotoxin detection, taking into account the LER issue, at the Parenteral Drug Association (PDA) Europe Conference held in Berlin, Germany on February 17, 2015.
http://www.pda.org/docs/default-source/attendee-presentations/europe/2015/pharmaceutical-microbiology/1_hughes_patricia.pdf?sfvrsn=2

January 28, 2015
A meta-analysis of four decades of studies on the concordance between Gram-negative (GN) bacteremia and endotoxemia was published in the Journal of Clinical Microbiology (JCM 2015; 53(4):1183-91). This important article discussed the reasons behind the weak concordance of endotoxemia with GN bacteremia. It is considered that the LAL reactivity to (1→3)-β-D-glucans and plasma pretreatment techniques should have had a huge impact on the matter along with LAL sensitivity to endotoxins involving the choice of the LAL assay format.

December 24, 2014
Since September 2012, the Centers for Disease Control and Prevention (CDC) has been investigating an unprecedented outbreak of fungal meningitis associated with contaminated methylprednisolone acetate (MPA) injections used in epidural steroid treatments. By October 2013, 751 cases were identified and 64 deaths were reported in this regard, thus, making this fungal infection as one of the largest recorded healthcare-associated outbreaks in the history of the United States. It should be noted that a black mold, Exserohilum rostratum, was identified as the predominant organism involved in these cases. In addition, CSF (1?3)-β-D-glucan levels with FDA-approved Fungitell assay may contribute to the rapid diagnosis of fungal meningitis caused by contaminated MPA injections with considerably high sensitivity and specificity (Malani et al. 2015. J.Clin.Microbiol. 53:799-803; Litvintseva et al. 2014. Clin.Infct.Dis. 58:622-30).
http://www.bostonglobe.com/metro/specials/meningitis/

December 5-6, 2014
The 20^th Annual Japan Endotoxin & Innate Immunity Society (JEIIS) meeting was organized by Prof. Isao Nagaoka (Juntendo University) at the Century Tower, Juntendo University on December 5-6, 2014. The head of LPS Consulting Office, Dr. Hiroshi Tamura, chaired the Luncheon Seminar on the current developments in endotoxin testing.
http://www.shiga-med.ac.jp/~jesmail/_userdata/JEIIS2014.pdf(Japanese)

November 17, 2014
The Japan Bioindustry Association (JBA) hosted a seminar titled “New trends in peptide research” at the JBA, Tokyo, Japan on November 17, 2014. This seminar was organized by Prof. Isao Nagaoka, Juntendo University, Japan and was presided by the head of LPS Consulting Office, Dr. Hiroshi Tamura. Two guest speakers (Dr. Jun Ishibashi, National Institute of the Agrobiological Sciences and Prof. Hiroaki Suga, The University of Tokyo) also joined the seminar.
http://www.jbda.org/seminar/index.html(Japanese)

October 23-25, 2014
The following oral presentation was given by Dr. Kaori Suzuki at the 2014 Annual Joint Meeting of Society for Leukocyte Biology & International Endotoxin Innate Immunity Society held in Salt Lake City, Utah on October 23-25, 2014. It seems to have had a greater impact on the various functional perspectives of antimicrobial peptides.

Human Host Defense Peptide Ll-37 Enhances the LPS Uptake by Endothelial Cells without Cell Activation: a Possible Role in the LPS Clearance
Kaori Suzuki, Zhongshuang Hu, Hiroshi Tamura and Isao Nagaoka
Department of Host Defense and Biochemical Research, Juntendo University Graduate School of Medicine, Tokyo, Japan, Kaori Suzuki, Juntendo University School of Medicine
http://leukocytebiology.org/PDFs/2014-Conference/2014_SLB_IEIIS_Abstracts.aspx

June 28, 2014
The 23^rd annual meeting on endotoxin/lipopolysaccharide(LPS) research was organized by Prof. Naohito Ohno (Tokyo University of Pharmacy and Life Sciences).
It was held at the Century Tower, Juntendo University. The head of LPS Consulting Office, Dr. Hiroshi Tamura served as chairperson at the meeting.
http://www.ps.toyaku.ac.jp/wp/menekigaku/wp-content/uploads/2014/05/10fe14d6d32d4554dbb4df8375ee8c50.pdf(Japanese)

May-June, 2014
The head of LPS Consulting Office, Dr. Hiroshi Tamura served as a visiting lecturer in the undergraduate seminar organized by Prof. Naohito Ohno (Tokyo University of Pharmacy and Life Science).

March 25, 2014
An article on LPS Consulting Office was published in Mr.Partner Book, Seiun-Sha　Co. Ltd.,Tokyo (in Japanese).
http://www.mrpartner.co.jp/cyukore2014/local/04.html

January 8, 2014
The head of LPS Consulting Office, Hiroshi Tamura took up a new role as the Chairman
of DAAJ (DNA advisor association of Japan).
http://daaj.org/(Japanese)

January 16, 2014
An interesting paper by Dr. Zhongshuang Hu et al. titled “Antimicrobial Cathelicidin Peptide LL-37 Inhibits the LPS/ATP-Induced Pyroptosis of Macrophages by Dual Mechanism” was published in online journal PLoS ONE.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085765

November 11, 2013
Juntendo University hosted seminar titled “The front line of peptide research and application” was held at the conference room, Juntendo University through two guest speakers (Dr. Jun Ishibashi, National Institute of the Agrobiological Sciences and Prof. Hiroaki Suga, The University of Tokyo). The seminar organizers were Profs. Isao Nagaoka and Keiichi Hiramatsu at Juntendo University, and Dr. Hiroshi Tamura of LPS Consulting Office.
83y83v836083h8CA48B8682CC8DC591O90FC.pdf

October 9-10, 2013
PropGene, Inc. exhibited their competitive products and services at BioJapan 2013 held in Yokohama, based on the direct-to-consumer (DTC) genetic testing.
http://www.pgi.jp/info_e/index_e.html

August 1, 2013
An article on LPS Consulting Office was published in Company Tank, IIM Co., Ltd., Tokyo (in Japanese).
http://www.fujisan.co.jp/product/1281681553/b/966181/(Japanese)

April-May, 2013
The head of LPS Consulting Office, Dr. Hiroshi Tamura served as a visiting lecturer in the undergraduate seminar organized by Prof. Naohito Ohno (Tokyo University of Pharmacy and Life Science).